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LEAPChem Supplies Dexamethasone (50-02-2) today

Nov. 2019/3/22 14:04:09 By LEAP Chem


At LEAPChem, we proudly distribute the materials that are required for the wide range of our customers’ production processes. We understand that each production process is unique, which is why we provide custom services and chemical knowledge tailored to each customer specifically. With LEAPChem, you can look forward to receiving the operational benefits of working with an international company paired with the customer service and reliable follow up of a small business. LEAPChem - Pharmaceutical Chemicals is happy to highlight Dexamethasone, a very promising chemical in the global chemical market.

 

Basic Information of Dexamethasone

Chemical Name: Dexamethasone

Cas No.: 50-02-2

Molecular Formula: C22H29FO5

Chemical Structure:

 50-02-2.png

 

Dexamethasone is a type of corticosteroid medication. It is used in the treatment of many conditions, including rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, and along with antibiotics in tuberculosis. In adrenocortical insufficiency, it should be used together with a medication that has greater mineralocorticoid effects such as fludrocortisone. In preterm labor, it may be used to improve outcomes in the baby. It may be taken by mouth, as an injection into a muscle, or intravenously. The effects of dexamethasone are frequently seen within a day and last for about three days.

The long-term use of dexamethasone may result in thrush, bone loss, cataracts, easy bruising, or muscle weakness. It is pregnancy category C in the United States meaning use should be based on benefits being predicted to be greater than risks. In Australia, it is category A, meaning it has been frequently used in pregnancy and not been found to cause problems to the baby. It should not be taken when breastfeeding.

Dexamethasone has anti-inflammatory and immunosuppressant effects.

Dexamethasone is used to treat many inflammatory and autoimmune conditions, such as rheumatoid arthritis and bronchospasm. Idiopathic thrombocytopenic purpura, a decrease in numbers of platelets due to an immune problem, responds to 40 mg daily for four days; it may be administered in 14-day cycles. It is unclear whether dexamethasone in this condition is significantly better than other glucocorticoids.

People with cancer undergoing chemotherapy are often given dexamethasone to counteract certain side effects of their antitumor treatments. Dexamethasone can increase the antiemetic effect of 5-HT3 receptor antagonists, such as ondansetron. The exact mechanism of this interaction is not well-defined, but it has been theorized that this effect may be due to, among many other causes, inhibition of prostaglandin synthesis, anti-inflammatory effects, immunosuppressive effects, decreased release of endogenous opioids, or a combination of the aforementioned.

Dexamethasone is a synthetic pregnane corticosteroid and derivative of cortisol (hydrocortisone) and is also known as 1-dehydro-9α-fluoro-16α-methylhydrocortisone or as 9α-fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione.

To synthesize dexamethasone, 16β-methylprednisolone acetate is dehydrated to the 9,11-dehydro derivative. This is then reacted with a source of hypobromite, such as basic N-bromosuccinimide, to form the 9α-bromo-11β-hydrin derivative, which is then ring-closed to an epoxide. A ring-opening reaction with hydrogen fluoride in tetrahydrofuran gives dexamethasone.

LEAPChem is continually expanding its scope within the pharmaceutical chemicals industry. Our passion for professional development enables us to accommodate our customers’ chemical requirements, and to distribute chemicals with applications that span several classes and functions.


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References:

https://en.wikipedia.org/wiki/Dexamethasone

https://www.ncbi.nlm.nih.gov/pubmed/5324105

https://www.ncbi.nlm.nih.gov/pubmed/11732953

 

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